tissue activator

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• Tissue plasminogen activator — (abbreviated tPA or PLAT) is a protein involved in the breakdown of blood clots. Specifically, it is a serine protease (EC number|3.4.21.68) found on endothelial cells, the cells that line the blood vessels. As an enzyme, it catalyzes the… …   Wikipedia

• tissue plasminogen activator — n a clot dissolving enzyme that has an affinity for fibrin, that catalyzes the conversion of plasminogen to plasmin, that is produced naturally in blood vessel linings, and that is used in a genetically engineered form to prevent damage to heart… …   Medical dictionary

• tissue plasminogen activator — n. an enzyme produced by the blood vessels that dissolves blood clots by converting plasminogen into plasmin: it is manufactured using recombinant DNA technology and used to prevent stroke, etc …   English World dictionary

• tissue plasminogen activator — noun a thrombolytic agent (trade name Activase) that causes fibrinolysis at the site of a blood clot; used in treating acute myocardial infarction • Syn: ↑Activase • Usage Domain: ↑trade name (for: ↑Activase) • Hypernyms: ↑ …   Useful english dictionary

• tissue plasminogen activator — An enzyme made in the body that helps dissolve blood clots. A form of this enzyme is made in the laboratory to treat heart attacks, strokes, and clots in the lungs. It is also being studied in the treatment of cancer. Tissue plasminogen activator …   English dictionary of cancer terms

• activator — 1. A substance that renders another substance, or catalyst, active, or that accelerates a process or reaction. 2. The fragment, produced by chemical cleavage of a proactivator, that induces the enzymic activity of another …   Medical dictionary

• activator — noun (biology) any agency bringing about activation; a molecule that increases the activity of an enzyme or a protein that increases the production of a gene product in DNA transcription • Ant: ↑inhibitor • Derivationally related forms: ↑activate …   Useful english dictionary

• tissueplasminogen activator — tissue plasminogen activator n. Abbr. TPA or tPA 1. A clot dissolving enzyme that is produced naturally by cells in the walls of blood vessels and catalyzes the conversion of plasminogen to plasmin. 2. A preparation of this enzyme that is… …   Universalium

• tissue plasminogen activator — noun Date: 1981 a clot dissolving enzyme with an affinity for fibrin that is produced naturally in blood vessel linings and is used in a genetically engineered form to prevent damage to heart muscle following a heart attack and reduce… …   New Collegiate Dictionary

• Tissue plasminogen activator — Activateur tissulaire du plasminogène Fibrinolyse. L activateur tissulaire du plasminogène (t PA) est une enzyme protéolytique initiant la fibrinolyse. Elle est sécrété par l endothélium vasculaire plusieurs jours après lésion de celui ci et son… …   Wikipédia en Français

• tissue plasminogen activator — (= TPA; tPA) Plasma serine protease, one of a closely related group of plasminogen activators. Contains an EGF like domain and multiple copies of the kringle domain …   Dictionary of molecular biology